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ENZYME CHANGES IN THE PLASMA AND PERITONEAL EXUDATE OF THE RAT FOLLOWING PANCREATIC DUCT OBSTRUCTION
Author(s) -
Herriott BA,
Palmer AA
Publication year - 1964
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1964.3
Subject(s) - amylase , exudate , pancreatic duct , lipase , medicine , ligation , endocrinology , enzyme , duct (anatomy) , gastroenterology , pancreas , chemistry , pathology , biochemistry
Summary Amylase and lipase activity in the plasma and amylase activity in the peritoneal exudate have been followed in female albino rats after pancreatic duct obstruction with bile bypass and after obstruction to the common pancreaticobiliary duct. The enzyme activities rose rapidly to a maximum in 6 to 12 hours after operation; thereafter in rats with pancreaticobiliary duct ligation the levels fell at first rapidly and then more slowly; when the pancreatic duet alone was obstructed a second peak of activity occurred at 24 hours. When the enzyme levels were raised the ratio of amylase activity in the peritoneal exudate to that in the plasma became reversed from the normal and remained fairly steady at the altered value of about 14:1. With obstruction to the pancreatic duct alone there was a close correlation between peritoneal exudate amylase and plasma amylase in rats killed at the same time after operation; the correlation was not so close when the pancreaticobiliary duct was obstructed. The ratio of plasma amylase to plasma lipase fluctuated with time after operation.