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THE BASIS FOR IMMUNITY TO MOUSE TYPHOID
Author(s) -
Jenkin CR,
Rowley D,
Auzins I
Publication year - 1964
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1964.23
Subject(s) - typhoid fever , salmonella , immunity , biology , virulence , microbiology and biotechnology , population , salmonella typhi , superinfection , strain (injury) , phagocytosis , virology , bacteria , immunology , immune system , virus , medicine , escherichia coli , genetics , gene , environmental health , anatomy
Summary A study has been made of the carrier state in mouse typhoid. The carrier state was induced using an avirulent strain of Salmonella typhimurium . The results indicate that the enhanced resistance to superinfection with the virulent strain of Salmonella typhimurium during this period is due to the production of specific antibody and not to any specific peculiarity of the phagocytic cells. The persistence of bacteria in tho reticulo‐endothelial system has been shown to be due to a heterogeneity in the bactericidal properties of the population of phagocytic cells. The importance of these observations with reference to the concept of cellular immunity is discussed.