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THE EFFECT OF TRAUMATIC SHOCK ON METABOLISM OF ETHYL ALCOHOL IN MICE
Author(s) -
Lykke AWJ,
Kosche ER
Publication year - 1964
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1964.19
Subject(s) - alcohol , ethanol , litter , intraperitoneal injection , metabolism , ethanol metabolism , chemistry , ethyl chloride , zoology , medicine , biochemistry , biology , ecology , nuclear chemistry
Summary In a controlled experiment using 27 pairs of litter‐mate white mice matched for weight, the rates of whole body metabolism of ethyl alcohol after intraperitoneal injection of ethyl alcohol were found to be significantly slower in animals in which a closed fracture of the femur was produced at the time of ethyl alcohol injection. Significant depressions of ethyl alcohol metabolism were found at 1, 1½ and 2 hours after production of the fracture. There was no significant interaction between treatments (i.e. the fracture versus the control) and the times at which estimations were made, but the rates of ethyl alcohol metabolism in control and fractured animals were significantly slower in the period 1½‐2 hours than in the period 1–1½ hours after ethyl alcohol injection. There was no significant sequestration of ethyl alchol in the fracture site, nor was there a significant difference between control and fractured animals in the whole‐body concentration of endogenous produced ethyl alcohol.