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THE INFLUENCE OF SPLENECTOMY IN NZB MICE
Author(s) -
Holmes Margaret C,
Burnet FM
Publication year - 1963
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1963.65
Subject(s) - splenectomy , incidence (geometry) , coombs test , medicine , spleen , immunology , antibody , physics , optics
SUMMARY Splenectomy has been performed in mice of the “autoimmune” strain NZB either at one to four months of age (early) or after eight months of age when the Coombs positive state is established (late). Early splenectomy increased the incidence of lethal nephritis in both males and females but significantly diminished survival time only in females. It also delayed conversion to the Coombs positive state and diminished other manifestations of the haemolytic process in males. Late splenectomy showed no significant results in these respects.