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THE EFFECT OF VASOPRESSIN ON WATER AND ELECTROLYTE EXCRETION BY THE SHEEP
Author(s) -
Cross RB,
Thornton WM,
Tweddell ED
Publication year - 1963
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1963.52
Subject(s) - vasopressin , reabsorption , endocrinology , medicine , chemistry , excretion , electrolyte , urine , kidney , electrode
SUMMARY The acute effects of vasopressin (40 mU) were studied in the conscious sheep. Vasopressin caused consistent increases in K and C1 excretion and variable increases in Na and total solute output. These changes occurred within 10 min., reached a peak within 30 min. and subsided within 60 min. When the urine was initially dilute (< 800 μosmoles/ml.) vasopressin caused an antidiuresis. When the original concentration exceeded 1000 (μosmoles/ml. vasopressin caused small increases in urine flow. Vasopressin always increased water reabsorption relative to solute reabsorption.