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ACTIONS OF METAL CHELATES OF SUBSTITUTED 1,10‐PHENANTHROLINES ON VIRUSES AND CELLS
Author(s) -
White David O,
Harris Alan W,
Dwyer Francis P,
Shulman Albert
Publication year - 1963
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1963.42
Subject(s) - chelation , antigenicity , infectivity , chemistry , metal , adsorption , virus , hemagglutination , virology , biology , inorganic chemistry , organic chemistry , immunology , antigen
SUMMARY Some metal chelates of substituted 1, 10‐phenanthrolines inactivate the infectivity of certain viruses. Other viral properties, including haemagglutination, antigenicity and the capacity to adsorb to host cells, are also affected, though to a lesser extent. The interaction between virus and chelate is partly reversible, since the haemagglutinating capacity of treated virus can be restored by washing. The relation between chemical structure and activity of various chelates as well as the sensitivity of viruses of differing chemical constitution, indicates that the chelates act purely physically following adsorption to the viral surface.