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CEREBROSPINAL FLUID BILIRUBIN AND ICTERUS OF THE RABBIT BRAIN
Author(s) -
Watson D,
Szego G
Publication year - 1963
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1963.40
Subject(s) - kernicterus , cerebrospinal fluid , bilirubin , albumin , blood–brain barrier , medicine , serum albumin , pathology , endocrinology , chemistry , central nervous system
SUMMARY Intracerebral injection of the alkylating agent N‐ethyl maleimide facilitated the entry of albumin‐bound bilirubin into the cerebrospinal fluid of adult rabbits. Animals in which very high CSF‐bilirubin levels (> 10 μg./ml.) had been induced showed cerebral icterus. In other animals, no correlation was observed between the CSF‐bilirubin concentration (in the range 1–4 μg./ml.) and the degree of cerebral icterus. The rabbit brain made hypersensitive by experimental allergic encephalomyelitis showed no abnormal entry of bilirubin. The type and degree of change is different from that observed in kernicterus. However, present observations are presented to demonstrate the kind of factor which can affect the normal blood‐CSF barrier.