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PULMONARY DAMAGE DUE TO HIGH PRESSURE OXYGEN BREATHING IN RATS
Author(s) -
Jamieson Dana,
Ladner Kathryn,
Brenk HAS
Publication year - 1963
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1963.38
Subject(s) - lung , pentobarbital , chemistry , oxygen , breathing , anesthesia , sodium , medicine , endocrinology , organic chemistry
SUMMARY The sulphydryl and disulphide contents of rat lungs were measured before and after exposure of rats to oxygen at 5 atmospheres absolute (OHP). After 45 minutes at this pressure lung damage occurred, and a decrease in ‐SH groups together with an increase in ‐SS‐ groups was found, such that the ‐SH/‐SS‐ ratio in the lung tissue was halved. Injections of pentobarbital sodium, which protect against OHP lung damage, reduce auto‐oxidation of ‐SH content of lung homogenate exposed to air in euro and also reduce ‐SH oxidation in lungs of OHP exposed rats.