Premium
THE REDUCTION OF THE PRESSOR ACTION OF ANGIOTENSIN II IN SODIUM‐DEFICIENT CONSCIOUS SHEEP
Author(s) -
BlairWest JR,
Coghlan JP,
Denton DA,
Coding JR,
Munro JA,
Wright RD
Publication year - 1963
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1963.37
Subject(s) - aldosterone , angiotensin ii , sodium , medicine , renin–angiotensin system , endocrinology , pressor response , epinephrine , vasoconstrictor agents , hormone , chemistry , blood pressure , heart rate , organic chemistry
SUMMARY The pressor effect of intravenous infusion of antiotensin II in sheep was greatly reduced by sodium deficiency. There was a similar reduction in the pressor effect of Neosynephrine, Aramine and adrenaline. The significance of this finding is discussed in the light of the proposition that angiotensin II is the aldosterone stimulating hormone. In sodium depletion catecholamines in low doses produced cardiac dysrhythmias.