THE EFFECT OF BILE SALTS ON CONTRACTION OF VISCERAL SMOOTH MUSCLE | Zendy

Laurence BH | Zendy; Simmonds WJ | Zendy

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THE EFFECT OF BILE SALTS ON CONTRACTION OF VISCERAL SMOOTH MUSCLE

Author(s) -

Laurence BH,

Simmonds WJ

Publication year - 1963

Publication title -

australian journal of experimental biology and medical science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.999

H-Index - 104

eISSN - 1440-1711

pISSN - 0004-945X

DOI - 10.1038/icb.1963.34

Subject(s) - toad , calcium , contraction (grammar) , chemistry , ileum , isometric exercise , acetylcholine , biophysics , smooth muscle , medicine , depolarization , muscle contraction , sodium , endocrinology , excitation–contraction coupling , muscle contracture , anatomy , biochemistry , biology , organic chemistry

SUMMARY Sodium taurocholate, 0·125 to 2·0 mg./ml. bath fluid, reversibly inhibited isometric contractions of rat's ileum in response to Ach, 10 −8 to 10 −4 . The degree of inhibition depended on the relative proportions of the two substances. In depolarizing solution, K 2 SO 4 ‐Ringer, taurocholate inhibited the Ach response of rat's ileum, rat's uterus and circular muscle of toad's stomach. In calcium‐free K 2 SO 4 ‐Ringer taurocholate inhibited calcium contractures in these three preparations. It is suggested that taurocholate may interfere with a mechanism coupling excitation to contraction and involving calcium.

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