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THE ADHESION OF LEUCOCYTES TO VASCULAR ENDOTHELIUM
Author(s) -
McGovern VJ,
Bloomfield D
Publication year - 1963
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1963.14
Subject(s) - adventitia , endothelium , adhesion , chemistry , vein , immunology , medicine , pathology , organic chemistry
SUMMARY Injury, traumatic or by injection of chemical substances, to the adventitia of the rat's femoral vein was followed after 1 1 / 2 hours by aggregation of polymorphonuclear leucocytes to the apparently normal endothelial surface of the vessel. Sub‐thrombotic injury to the endothelium, however, was followed by adhesion of leucocytes almost immediately to the injured area and within 30 minutes, leucocytes adhered also to apparently normal endothelium in the line of flow immediately beyond the injured area. These observations lead to the supposition that the aggregation of leucocytes upon apparently normal endothelium may be due to a substance released from the site of injury which either confers upon the endothelial surface an attraction for leucocytes or else neutralizes the power to repel them.