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THE STAPHYLOCOCCAL INTERFERENCE EFFECT
Author(s) -
Pawlyszyn G
Publication year - 1963
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1963.10
Subject(s) - staphylococcus aureus , hapten , microbiology and biotechnology , antibody , biology , staphylococcus , antigen , hemagglutination , immune system , strain (injury) , bacteria , immunology , anatomy , genetics
SUMMARY Staphylococcus albus has a genus specific component, probably a polysaccharide, which has the property of sensitising sheep and mouse erythrocytes for haemagglutination and of producing an interference type of protection in mice. Antibodies to this component can be detected in sera of rabbits immunised with either Staphlyococcus aureus or Staphylococcus albus . Although both albus and aureus strains could produce the “interference” effect, only the latter organism was found to be able to produce protective antibodies. Such antibodies could be removed from the immune serum by absorption with Staphylococcus albus organisms, suggesting that this strain possesses a hapten‐like substance which is a part of the complete protective antigen present in the aureus strain. The possibility that the hapten‐like substance is the component which produces interference protection is being considered.