Premium
PULMONARY DAMAGE DUE TO HIGH PRESSURE OXYGEN BREATHING IN RATS
Author(s) -
Brenk HAS,
Jamieson Dana
Publication year - 1962
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1962.6
Subject(s) - atelectasis , lung , oxygen toxicity , oxygen , medicine , anesthesia , histology , pathology , chemistry , organic chemistry
SUMMARY Changes in lung weights, histology and bronchographic appearances are recorded in rats subjected to oxygen at 60 p.s.i. (gauge) pressure (OHP). Capillary congestion, progressing to alveolar exudation and haemorrhage, was the earliest observable change. The results failed to support a postulate that lung damage due to oxygen poisoning is primarily an atelectasis due to bronchial obstruction. Positive pressure inflation of lungs immediately post mortem , did not reverse oxygen damage. Heparinisation of rats was also without effect on such damage. Exposure of lung tissue in vitro to 100 p.s.i. (gauge) pressure of oxygen for five hours failed to cause changes similar to those observed for OHP lungs exposed in vivo .