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PULMONARY DAMAGE DUE TO HIGH PRESSURE OXYGEN BREATHING IN RATS
Author(s) -
Jamieson Dana,
Brenk HAS
Publication year - 1962
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1962.34
Subject(s) - evans blue , ventricle , lung , oxygen , vascular permeability , chemistry , medicine , plasma volume , endocrinology , anesthesia , organic chemistry
SUMMARY The Evans Blue dye technique has been used to determine the increase in capillary permeability in lungs of rats subjected to pure oxygen under pressure at 60 p.s.i. gauge (OHP). Considerable leakage of plasma during exposure to OHP was found. Haemoglobin in lung tissue also increased markedly during OHP treatment. Blood removed from the left ventricle showed an increase in the haematocrit value, red blood cell count and haemoglobin concentration after OHP. Of the amounts of fluids entering the lungs a total of 56 p.c. was attributable to plasma of which 18 p.c. represented a gain in blood volume. The remaining gain in weight of 44 p.c. was due to a protein‐free fluid. The sequence and relative amounts of fluids entering the lung are discussed.