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SOME TISSUE CHANGES IN THE DOG FOLLOWING STILBOESTROL ADMINISTRATION
Author(s) -
Jabara Anne G
Publication year - 1962
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1962.33
Subject(s) - medicine , atrophy , diethylstilbestrol , pyometra , hyperplasia , endocrinology , physiology , hormone , uterus
SUMMARY Dogs (18 female, 4 male) receiving subcutaneous depot injections of diethylstilboestrol at intervals of 4–6 weeks developed alopecia after 11 months. All areas except the head and distal parts of the legs were affected and the denuded skin became dry, scaly and excoriated. Microscopic changes were observed in all elements of the skin and the hair follicles were atrophic. The hair grew again 3–7 months after injections were stopped, and at necropsy 11–14½ months later the skin was histologically normal. Other findings included testicular atrophy, a high incidence of inguinal hernia, and endometrial hyperplasia which progressed to a cystic stage and eventually to pyometra. When injections were stopped the endometrium regenerated after an interval the duration of which was independent of the duration of treatment or of total dose administered, but may have been related to the time taken to deplete the residual depot. Treated dogs also showed an increase of pituitary acidophils and a reduction in basophils and chromophobes; these changes were reversed on hormone withdrawal. Generalized or focal atrophy of the pancreas occurred in four of the longer surviving dogs; this was regarded as a toxic effect of stilboestrol.

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