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ON THE QUESTION OF THE SPECIFICITY OF CELLULAR IMMUNITY
Author(s) -
Auzins Ieva,
Rowley D
Publication year - 1962
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1962.32
Subject(s) - opsonin , lipopolysaccharide , immunity , metabolic activity , macrophage , acid phosphatase , microbiology and biotechnology , cellular immunity , chemistry , phosphatase , enzyme , biology , phagocytosis , immunology , immune system , biochemistry , in vitro , biological system
SUMMARY Macrophages obtained from mice 24 hours after injection of lipopolysaccharide extracted from E. coli 2206 have been shown to be more phagocytic and bactericidal for opsonized E. coli 2206 than are macrophages obtained from normal mice. This increased cellular resistance has been shown to be non‐specific since the bactericidal activity of these macrophages is also greater than that of normal cells against Sal. typhimurium C5. A correlation has been shown between this increased cellular resistance and the increased metabolic activity of these cells. Changes in metabolic activities of the macrophages have been measured in terms of the enzyme acid phosphatase.