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TOLERANCE AS SHOWN BY THE SIMONSEN REACTION ON THE CHORIOALLANTOIC MEMBRANE
Author(s) -
Hilgard H,
Burnet Deborah,
Burnet FM
Publication year - 1962
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1962.27
Subject(s) - chorioallantoic membrane , embryo , biology , spleen , microbiology and biotechnology , embryonic stem cell , antigen , immunology , andrology , genetics , medicine , gene
SUMMARY By prenatal administration of embryonic spleen cells, chickens can be rendered tolerant in the sense that their circulating leucocytes are incapable of producing focal lesions on the chorioallantoic membranes of embryos of genotypes corresponding to those of the cell donors. In most of the experiments reported the extent of tolerance diminished rapidly as the birds grew older but in some of the pure line chickens persisting tolerance suggests that on occasion the effect may last indefinitely. The significance of antigenic specificity in the Simonsen reaction is briefly discussed.