Premium
THE METABOLISM OF ISONIAZID AND PYRIDINE ALDEHYDES BY MYCOBACTERIA
Author(s) -
Youatt Jean
Publication year - 1962
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1962.21
Subject(s) - isoniazid , pyridine , enzyme , aldehyde , metabolism , mycobacterium tuberculosis , chemistry , biochemistry , organic chemistry , tuberculosis , stereochemistry , medicine , catalysis , pathology
SUMMARY 3‐ and 4‐pyridine aldehydes were metabolised by Mycobacterium tuberculosis BCG with the production of the corresponding acids and alcohols. The breakdown of isoniazid and the pyridine aldehydes was also observed in cell‐free extracts and some purification of the enzymes involved was achieved. It is suggested that there are two enzyme systems which metabolise isoniazid of which one may involve the intermediate formation of 4‐pyridine aldehyde.