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QUANTITATIVE ASPECTS OF THE SIMONSEN PHENOMENON
Author(s) -
Lind Patricia E,
Szenberg A
Publication year - 1961
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1961.51
Subject(s) - biology , fowl , immunity , antigen , immune system , immunology , hemagglutination , embryo , virology , microbiology and biotechnology , paleontology
SUMMARY Immunization of adult fowls with embryonic tissue does not increase the ability of their blood large lymphocytes to produce lesions on the chorio‐allantoic membrane. The results of Coombs' tests and of haemagglutination tests indicate that inoculation of spleens from 16–18 day embryos provides an antigenic stimulus in the adult fowl, but that 12‐day embryonic spleens evoke no detectable immune response. The bearing of these findings on the application of the clonal selection theory of acquired immunity to the Simonsen phenomenon is discussed.