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A COMPARATIVE STUDY OF BLOOD COAGULATION IN VERTEBRATES
Author(s) -
Fantl P
Publication year - 1961
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1961.41
Subject(s) - biology , clotting factor , fibrinogen , lizard , thromboplastin , chemistry , coagulation , medicine , zoology , biochemistry
SUMMARY The addition of kaolin suspension and phospholipid shortens the clotting time of plasma of toad, trout, echidna, tortoise, possum, dog, guinea pig, rat, man and lizard. Kaolin has little influence on the plasma clotting time of the domestic fowl, teal and tiger snake. The duration of incubation of plasma with kaolin suspension and phospholipid to produce shortest clotting time varies from less than one minute in the plasma of the first four vertebrates to several minutes in the plasma of lizards and man. The kaolin‐activated clotting factors are very unstable in plasma of toad, trout, tortoise and echidna and stable for several minutes in the plasma of the other vertebrates. The addition of bird or snake plasma does not correct the coagulation defect of human plasma congenitally deficient in Hageman factor. Toad plasma has a low activity in this respect. Thromboplastin formation takes place in all the examined plasma but is low, in decreasing order, in the plasma of lizard, tortoise and tiger snake. In the conversion of prothrombin homologous lung suspensions are usually more active than heterologous ones. Clotting times obtained in the presence of Russell's viper venom or trypsin indicate a low prothrombin activity in the plasma of the tiger snake. In the plasma of the tiger snake the rate of reaction of thrombin with fibrinogen and the fibrinogen concentration are adequate for haemostasis.