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FOLIC ACID DEFICIENCY AND URINARY FORMIMINOGLUTAMIC ACID EXCRETION IN THE RAT
Author(s) -
Davis RE
Publication year - 1961
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1961.40
Subject(s) - excretion , urine , folic acid , medicine , endocrinology , vitamin , urinary system , chemistry
SUMMARY Rats fed on a folic acid‐deficient diet regularly excrete formiminoglutamic acid in the urine. The vitamin B 12 and folic acid status of such rats was estimated by assay of liver tissue for these vitamins. Formiminoglutamic acid excretion occurs in the presence of normal liver vitamin B 12 concentrations. There appears to be a critical level of liver folic acid below which there is excretion of formiminoglutamic acid.