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THE MECHANISM OF ABSORPTION OF SUBCUTANEOUS EXTRAVASATIONS OF BLOOD
Author(s) -
Walsh RJ,
Cantrill Shirley
Publication year - 1961
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1961.37
Subject(s) - peritoneal cavity , absorption (acoustics) , subcutaneous injection , subcutaneous tissue , coagulation , chemistry , hyaluronidase , blood clotting , medicine , pathology , surgery , biochemistry , materials science , composite material , enzyme
SUMMARY The rate and mechanism of absorption of blood from subcutaneous extravasations has been investigated in rats. Absorption of intact red cells from the peritoneal cavity is rapid, but in the subcutaneous tissues red cells are mainly broken down in situ with absorption of catabolised products. A difference in the coagulation and lytic mechanisms in the peritoneal and subcutaneous tissues seems to account for the different absorption mechanisms. Simultaneous injections of anticoagulants, hyaluronidase, and streptoldnase did not increase the absorption of red cells. A large percentage of the Fe 59 or Cr 51 from broken‐down red cells passed to the liver.