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IRON STORAGE AND TRANSPORT AFTER ADMINISTRATION OF VIABLE ERYTHROCYTES TO THE ALBINO RAT
Author(s) -
Morgan EH
Publication year - 1961
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1961.35
Subject(s) - spleen , polycythaemia , ferritin , endocrinology , chemistry , medicine , biochemistry
SUMMARY Viable rat erythrocytes were administered intraperitoneally in two dosage levels to male albino rats. The changes in blood haemoglobin, plasma iron and total iron binding capacity (T.I.B.C.) and liver and spleen storage iron were followed for 180 days after giving the erythrocytes. Polycythaemia persisted for at least 20 days and was accompanied by elevation of the plasma iron concentration and depression of the T.I.B.C. During the first 20–60 days liver and spleen storage iron values increased markedly, but thereafter gradually declined. The increase in storage iron concentration was greater in the spleen than in the liver, and in the spleen relatively less iron was found in the ferritin fraction than in the haemosiderin fraction when compared with the values for control rats.