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THE INTERCONVERSION OF OESTRONE AND OESTRADIOL‐17 β BY HUMAN AND RAT BLOOD
Author(s) -
Brown BT,
Golder WS,
Wright SE
Publication year - 1961
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1961.33
Subject(s) - estrone , human blood , chemistry , yield (engineering) , chromatography , endocrinology , medicine , hormone , biochemistry , biology , physiology , materials science , metallurgy
SUMMARY The interconversion of oestrone and oestradiol‐17 β occurs in human and rat blood cells and to a lesser extent in plasma. Reduction of oestrone produces only oestradiol‐17 β which has been identified by preparation of its pipsylate. This can be separated from the pipsylate of oestradiol‐17 α by paper chromatography. Oestrone and oestradiot‐17 β also yield polar substances when incubated with blood preparations. The preparation and constants of a number of oestrogen pipsylates are described.
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