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THE INTERACTION OF STAPHYLOCOCCAL TOXIN AND GANGLIOSIDE
Author(s) -
Doery Hazel M,
North EA
Publication year - 1961
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1961.32
Subject(s) - ganglioside , neuraminidase , sialic acid , toxin , chemistry , aqueous solution , microbiology and biotechnology , biochemistry , biology , enzyme , organic chemistry
SUMMARY Evidence is presented that staphylococcal toxin and serum proteins form firm combinations with ganglioside. Ganglioside from which up to 62 p.c. of the sialic acid is removed by either heat or neuraminidase still strongly inactivates staphylococcal toxin. Sedimentation data are presented for unheated and heated aqueous solutions of ganglioside. These data, together with inactivation studies, support the idea that heated aqueous solutions form smaller or unfolded aggregates with more active sites available for interaction with toxins. Mechanisms of combination between gangliosides and proteins are discussed.