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THE ACTION OF PHOSPHATIDASE A, SODIUM OLEATE AND GANGLIOSIDE ON THE EXOTOXINS OF CL. WELCHII AND ON THE NEUROTOXIN OF SHIGELLA SHIGAE
Author(s) -
North EA,
Pawlyszyn G,
Doery Hazel M
Publication year - 1961
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1961.26
Subject(s) - ganglioside , clostridium perfringens , neurotoxin , microbiology and biotechnology , toxin , sodium , chemistry , shiga toxin , shigella dysenteriae , shigella , biology , bacteria , biochemistry , escherichia coli , organic chemistry , genetics , gene
SUMMARY The lethal effect of the exotoxins of Clostridium perfringens and Cl. ovitoxicum in mice is antagonised by phosphatidase A. In this respect, and in the fact that they are inactivated by sodium oleate and ganglioside in vitro , these toxins behave like those of Gram‐positive bacteria previously studied. By contrast phosphatidase A, sodium oleate and ganglioside do not protect against Shigella shigae neurotoxin. Previous work had indicated that inactivation of toxins by both sodium oleate and ganglioside was in the nature of non‐specific adsorption to protein, whilst Shiga toxin has been proved to be a protein. Comment is made on these and other points of interest.