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THE EFFECT OF COLLOIDAL SILICA ON BLOOD COAGULATION
Author(s) -
Margolis J
Publication year - 1961
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1961.25
Subject(s) - coagulation , colloidal silica , colloid , denaturation (fissile materials) , chemistry , adsorption , chromatography , particle (ecology) , chemical engineering , biophysics , organic chemistry , biology , nuclear chemistry , medicine , ecology , engineering , coating
SUMMARY Colloidal silica accelerates blood coagulation by adsorption and partial denaturation of a specific plasma protein, the Hageman factor. Quantitative measurements show that the activity of the silica depends on the particle diameter. It is suggested that geometrical relations between the silica and the protein molecules account for these differences in activity. The implications of certain anomalies of this reaction are considered.