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PHAGOCYTOSIS BY EOSINOPHILS FOLLOWING ANTIGEN‐ANTIBODY REACTIONS IN VITRO
Author(s) -
Archer GT,
Bosworth Nola
Publication year - 1961
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1961.15
Subject(s) - phagocytosis , zymosan , antigen , immune system , in vitro , antibody , immunology , biology , microbiology and biotechnology , chemistry , biochemistry
SUMMARY Phagocytosis by human and rat eosinophils was studied by means of an in vitro system consisting of red cells as antigen, immune serum and white cells. Erythrophagocytosis by the white cells, including eosinophils, occurred following the reaction between red cell antigens and fresh immune sera at room temperature. A high percentage of the eosinophils showed phagocytosis. The part played by complement in phagocytosis was investigated by means of immune serum inactivated by heat, hydrazine, zymosan and diethyl other. It was concluded that the first component is the only component of complement required for phagocytosis.