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THE DYNAMIC RED CELL STORAGE FUNCTION OF THE SPLEEN IN SHEEP
Author(s) -
Turner AW,
Hodgetts V Elizabeth
Publication year - 1960
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1960.9
Subject(s) - chlorpromazine , splenectomy , red cell , spleen , chemistry , endocrinology , medicine , anesthesia
SUMMARY Chlorpromazine (0·46–0·7 mg./kg. i.v.) caused profound fall of haematocrit in sheep. Its virtual abolition by splenectomy and its inverse relationship to splenic gamma radiation surface counts in intact sheep prepared with 51 Cr‐labelled red cells showed this to be due almost entirely to splenic relaxation and consequent increase of red cells held there. Plasma dilution through water shift played only a small part in the haematocrit fall Similar haematocrit fall, and its virtual abolition by splenectomy, occurred after dihydroergotamine but not after Dibenamine. Both these agents, as well as chlorpromazine, were shown to reduce the haematocrit response to adrenaline or nor ‐adrenaline. Haematocrit fall also occurred after pentobarbitonum sodium at a dose sufficient to produce obvious central effects. The relative importance of ataraxis and of splenic adrenergic blocking in the haematocrit‐reducing effect of chlorpromazine in sheep could not be wholly resolved, but the central effects are probably more important. Haematocrit fall, abolished by splenectomy, was also observed after mepazine (2·3 mg./kg. i.m.). The effect after meprobamate (9·4 mg./kg.) was slight.