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THE ANTISTAPHYLOCOCCAL ACTIVITY OF HUMAN SERA IN VITRO AND ITS RELATIONSHIP TO PASSIVE PROTECTIVE POTENCY
Author(s) -
Fisher Stephen
Publication year - 1960
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1960.36
Subject(s) - in vitro , potency , strain (injury) , microbiology and biotechnology , mucin , staphylococcus aureus , in vivo , chemistry , biology , bacteria , biochemistry , genetics , anatomy
SUMMARY The degree of bactericidal or bacteriostatic effect of human sera against coagulase producing staphylococci was found to vary according to strain and serum. The nature of the antibacterial agent is unknown. The ability of human sera to protect mice against the lethal effect of intraperitoneally injected living staphylococci of a certain strain (strain Smith) in mucin suspension appeared independent of the effect of the sera against the same strain in vitro. In a preparation of human gamma globulin, the mouse protective factor appeared to have been concentrated; divergent results were obtained in two kinds of test fro antibacterial activity in vitro.