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THE UPTAKE OF ISONIAZID AND RELATED COMPOUNDS BY MYCOBACTERIA
Author(s) -
Youatt Jean
Publication year - 1960
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1960.35
Subject(s) - isoniazid , hydrazide , sodium azide , chemistry , sodium cyanide , cyanide , isonicotinic acid , oxygen , nuclear chemistry , biochemistry , pharmacology , organic chemistry , tuberculosis , medicine , pathology
SUMMARY Other hydrazides inhibited the uptake of isoniazid. If the hydrazide group was substituted there was no inhibition. C 14 meotinic acid hydrazide was taken up at approximately one‐third of the rate of uptake of isoniazid. The uptake required oxygen and was sensitive to sodium cyanide and azide. In this the uptake resembled that of isoniazid, but there was no inhibition by other hydrazides even in large excess. Hydrazones of isoniazid were taken up by a different process which did not require oxygen and was insensitive to cyanide. These results are discussed in terms of the mode of action of isoniazid.