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TISSUE INJURY BY HIGH FREQUENCY ELECTRIC CURRENT: OBSERVATIONS WITH THE SANDISON‐CLARK EAR‐CHAMBER
Author(s) -
Buckley Ian K
Publication year - 1960
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1960.22
Subject(s) - vacuole , cytoplasm , in vivo , chemotaxis , biophysics , pathology , anatomy , chemistry , microbiology and biotechnology , biology , medicine , biochemistry , receptor
SUMMARY Injury by high frequency electric current to small groups of cells within the Sandison‐Clark rabbit ear‐chamber has demonstrated the in vivo development of blister‐like structures on injured cells and the subsequent separation of these to form free floating globular bodies. It is concluded that this process is responsible for the appearance of transparent globules within injured blood vessels and that it corresponds to a similar phenomenon frequently observed on cells in vitro. Further consequences of cellular injury were the very rapid formation of cytoplasmic vacuoles by some cells and the active migration of granular leucocytes to the site of injury. Leucocyte accumulation under these conditions strongly suggests a chemotactic effect by products of injured cells.