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THE POSITIVE INOTROPIC ACTIVITY OF PLASMA
Author(s) -
Nayler WG,
McCulloch M
Publication year - 1960
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1960.14
Subject(s) - inotrope , contractility , quinidine , medicine , calcium , chemistry , glycoside , plasma levels , endocrinology , organic chemistry
SUMMARY Plasma exerts a positive inotropic action on the isolated heart. The inotropic response is similar to that induced by the glycosides. DNP and quinidine sulphate both fail to depress the activity of plasma but abolish that of the glycosides. Plasma activity is increased when hearts are perfused in low calcium Ringer solution. Anterior pituitary extract restored the response of the winter heart to plasma. The possibility that plasma normally contains a substance which regulates myocardial contractility is discussed.