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THE EFFECT OF CORTISONE ON THE RELEASE OF GASTRIC ACID BY HISTAMINE
Author(s) -
Trethewie ER
Publication year - 1959
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1959.59
Subject(s) - cortisone , histamine , antihistamine , gastric acid , secretion , peptic , medicine , chemistry , endocrinology , cimetidine , histamine antagonists , perforation , peptic ulcer , pharmacology , punching , materials science , metallurgy
SUMMARY No particular increase in the concentration of gastric acid output has been observed even after large doses of cortisone. With large doses of histamine, in animals protected with antihistamine, hydrocortisone is associated with an increase in the volume of juice secreted, but there is no increase in acid concentration secreted. It is suggested that the damage of perforation or bleeding in peptic ulcer patients treated with cortisone may be due to cortisone inhibition of substances associated with healing rather than an effect on acid secretion.