Premium
CANINE OVARIAN TUMOURS FOLLOWING STILBOESTROL ADMINISTRATION
Author(s) -
Jabara Anne G
Publication year - 1959
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1959.57
Subject(s) - diethylstilbestrol , ovary , carcinogen , pathology , hyperplasia , medicine , physiology , biology , estrogen , biochemistry
SUMMARY Infection of diethylstilboestrol into a group of eight dogs was followed, within nineteen months, by development of tumours of the ovary in all cases. One of these was an hyperplasia and seven were definite neoplasms. The neoplastic nature of these was shown by invasion and development (in 3 cases) of metastases. The tumours showed, in these cases, a multiplicity of tissues not seen in tumours in man. The high yield indicates a specific activity of the injected material, either the stilboestrol itself or a metabolite, or its physiological activity provides a bulk of tissue on which some carcinogen acts.