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PLASMA CELL PROLIFERATION FOLLOWING WHOLE BODY IRRADIATION
Author(s) -
Nossal GJV
Publication year - 1959
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1959.51
Subject(s) - radioresistance , gastrointestinal tract , cell growth , plasma cell , irradiation , whole body irradiation , biology , regeneration (biology) , lymphocyte , cell , microbiology and biotechnology , immunology , antibody , cell culture , biochemistry , genetics , physics , nuclear physics , bone marrow
SUMMARY The effects of large doses of whole body irradiation on lymphoid tissues have been studied, with special reference to the normal plasma fell populations of the tissues. Plasma cells were found to be more radioresistant than lymphocytes. After a sublethal dose of 500 r of whole body X‐rays, considerable plasma cell proliferation followed. This plasma cell proliferation occurred earlier and was relatively more extensive than lymphocyte regeneration. The view is put forward that the plasma cell proliferation might represent an antibody response to invading micro‐organisms entering the irradiated animal via the damaged gastrointestinal tract.