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A STUDY OF THE METASTATIC DISTRIBUTION OF ERLICH ASCITES TUMOUR CELLS IN MICE
Author(s) -
Selecki EE
Publication year - 1959
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1959.50
Subject(s) - spleen , ascites , pathology , lung , neoplasm , metastasis , cell , intraperitoneal injection , distribution (mathematics) , chemistry , medicine , biology , immunology , cancer , mathematical analysis , mathematics , biochemistry
SUMMARY The introduction of a method of labelling ascites tumour cells with radioactive chromium has facilitated a quantitative study of metastasis of these cells. A rapid rate of removal of tumour cells from the blood stream takes place in the first 15 minutes after the intravenous injection of labelled tumour cells, and a corresponding rise in the number of tumour cells lodged in the lungs is observed at this time. A constant release of tumour cells from the lungs into the systemic circulation occurs immediately after the intravenous injection. The release is relatively slight in the first three hours, but after 24 hours only 5 p.c. of the number of cells accumulated remain in the lung. The liver accumulates about 20 p.c. of the total number of cells injected in the first six hours. The subsequent disappearance of the cells from the organ is slow. A steady accumulation of cells is observed in the spleen up to the third day after injection. The total number of cells reaching the spleen is small, but the concentration per gram of splenic tissue is relatively high.