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FIBRINOLYSIS FOLLOWING ELECTRICALLY INDUCED CONVULSIONS
Author(s) -
Fantl P,
Simon Shirley E
Publication year - 1948
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1948.54
Subject(s) - citation , library science , original research , medicine , psychology , computer science
The application in this hospital of alternating current for electro-convulsive therapy (E.C.T.) and electronarcbsis in certain mental disturhances afforded the opportunity of investigating the effects of this form of therapy on some of the components of the hlood. Schiitz (1942) ohserved in vitro a delayed coagulation of blood following application of a weak direct current. Brecht and Kummer (1943) noted a leucocytosis immediately after electrical shock; there was no alteration of hlood sugar or protein. Spiegel-Adolf, Spiegel et al. (1945) reported that following the application of a 60 cycle current at 30 volts for 1-2 seconds there were changes in cerehrospinal fluid suggesting the hreakdown of nuclear substances. This statement, however, has since heen contradicted by M. Ii. Hack (1947). Huddleson (1946) observed haemorrhages in the central nervous system in rats following electrical shock. Trojaniello (1947) indicated that dogs subjected to electrical shock by alternating current at 120 volts for a fraction of a second, showed no changes in blood lipase and diastase, but that phosphatase aetivity decreased for about 12 hours. Delay and Soulairac (1943) observed, following E.C.T. in human subjects, a transient inerease in blood albumin, and oeeasionally a slight increase in the globulin fraetion. There was a concomitant increase of blood calcium and inorganic phosphate. Purther, hyperglycemia, leucocytosis, and a decrease in the alkali reserve were demonstrable.