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Cuf2 boosts the transcription of APC/C activator Fzr1 to terminate the meiotic division cycle
Author(s) -
Aoi Yuki,
Arai Kunio,
Miyamoto Masaya,
Katsuta Yuji,
Yamashita Akira,
Sato Masamitsu,
Yamamoto Masayuki
Publication year - 2013
Publication title -
embo reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.584
H-Index - 184
eISSN - 1469-3178
pISSN - 1469-221X
DOI - 10.1038/embor.2013.52
Subject(s) - meiosis , biology , microbiology and biotechnology , cell cycle , cyclin , chromosome segregation , genetics , activator (genetics) , mitosis , transcription factor , cell division , anaphase , chromosome , gene , cell
The number of nuclear divisions in meiosis is strictly limited to two. Although the precise mechanism remains unknown, this seems to be achieved by adjusting the anaphase‐promoting complex/cyclosome (APC/C) activity to degrade cyclin. Here, we describe a fission yeast cuf2 mutant that enters into a third nuclear division cycle, represented by ectopic spindle assembly and abnormal chromosome segregation. Cuf2 is a meiotic transcription factor, and its critical target is fzr1 + /mfr1 + , which encodes a meiotic APC/C activator. fzr1 Δ also enters a third nuclear division. Thus, Cuf2 ensures termination of the M‐phase cycle by boosting Fzr1 expression to generate functional gametes.