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On the Rab again—the PATh to mTORC1 activation
Author(s) -
Gopaldass Navin,
Rompf Maria,
Mayer Andreas
Publication year - 2013
Publication title -
embo reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.584
H-Index - 184
eISSN - 1469-3178
pISSN - 1469-221X
DOI - 10.1038/embor.2013.48
Subject(s) - mtorc1 , autophagy , microbiology and biotechnology , rab , degradation (telecommunications) , amino acid transporter , transporter , chemistry , biochemistry , biology , gtpase , pi3k/akt/mtor pathway , gene , signal transduction , computer science , apoptosis , telecommunications
This month, Matsui and Fukuda report that Rab12 regulates autophagy indirectly by stimulating the constitutive degradation of the amino acid transporter PAT4. This negatively regulates mTORC1 and stimulates autophagy.