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SUMOylation of Blimp‐1 is critical for plasma cell differentiation
Author(s) -
Ying HsiaYuan,
Su ShinTang,
Hsu PangHung,
Chang CheChang,
Lin IYing,
Tseng YuHsuan,
Tsai MingDaw,
Shih HsiuMing,
Lin KuoI
Publication year - 2012
Publication title -
embo reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.584
H-Index - 184
eISSN - 1469-3178
pISSN - 1469-221X
DOI - 10.1038/embor.2012.60
Subject(s) - sumo protein , psychological repression , plasma cell , histone , microbiology and biotechnology , hdac1 , regulator , histone deacetylase 2 , ubiquitin ligase , cellular differentiation , biology , histone deacetylase , repressor , lysine , chemistry , ubiquitin , antibody , transcription factor , dna , genetics , gene expression , gene , amino acid
Transcriptional repressor B lymphocyte‐induced maturation protein‐1 (Blimp‐1) is a master regulator of plasma cell differentiation. Here we show that Blimp‐1 is covalently modified by SUMO1 at lysine 816, a modification mediated by SUMO E3 ligase PIAS1. Mutation of Blimp‐1 lysine 816 reduces transcriptional repression—correlating with a reduced interaction with a histone deacetylase, HDAC2—and impairs differentiation of antibody‐secreting cells. Thus, the SUMO pathway critically regulates Blimp‐1 function during plasma cell differentiation.