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Challenges in targeting cancer metabolism for cancer therapy
Author(s) -
Yamaguchi Ryuji,
Perkins Guy
Publication year - 2012
Publication title -
embo reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.584
H-Index - 184
eISSN - 1469-3178
pISSN - 1469-221X
DOI - 10.1038/embor.2012.176
Subject(s) - cancer , library science , medicine , gerontology , cancer research , computer science
A tumour mass contains tens of different somatic mutations, which makes it difficult to eliminate by targeting mutated gene products. A simpler approach could target the elevated levels of glycolysis common in cancer, but doing so might be just as complicated as targeting somatic mutations, if not more so.