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Through thick and thin: the conundrum of chromatin fibre folding in vivo
Author(s) -
Quénet Delphine,
McNally James G,
Dalal Yamini
Publication year - 2012
Publication title -
embo reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.584
H-Index - 184
eISSN - 1469-3178
pISSN - 1469-221X
DOI - 10.1038/embor.2012.143
Subject(s) - chromatin , microbiology and biotechnology , somatic cell , biology , folding (dsp implementation) , biophysics , genetics , dna , gene , engineering , structural engineering
The established view that chromatin is compacted into 30 nm fibres in the nucleus is being challenged. One of these studies is published in this issue of EMBO reports and shows that chromatin predominantly organizes as 10 nm fibres in somatic mouse cells. These recent data and their implications are discussed here.