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Hairless promotes PPARγ expression and is required for white adipogenesis
Author(s) -
Kumpf Susann,
Mihlan Michael,
Goginashvili Alexander,
Grandl Gerald,
Gehart Helmuth,
Godel Aurélie,
Schmidt Juliane,
Müller Julius,
Bezzi Marco,
Ittner Arne,
Guccione Ernesto,
Wolfrum Christian,
Ricci Romeo
Publication year - 2012
Publication title -
embo reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.584
H-Index - 184
eISSN - 1469-3178
pISSN - 1469-221X
DOI - 10.1038/embor.2012.133
Subject(s) - adipogenesis , hairless , microbiology and biotechnology , adipose tissue , adipocyte , white adipose tissue , transcription factor , transcription (linguistics) , energy homeostasis , chemistry , biology , medicine , endocrinology , gene , biochemistry , obesity , linguistics , philosophy
Adipose tissue is the largest compartment in the mammalian body for storing energy as fat, providing an important reservoir of fuel for maintaining whole body energy homeostasis. Herein, we identify the transcriptional cofactor hairless (HR) to be required for white adipogenesis. Moreover, forced expression of HR in non‐adipogenic precursor cells induces adipogenic gene expression and enhances adipocyte formation under permissive conditions. HR exerts its proadipogenic effects by regulating the expression of PPARγ, one of the central adipogenic transcription factors. In conclusion, our data provide a new mechanism required for white adipogenesis.