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MCL1 meets its end during mitotic arrest
Author(s) -
Millman Scott E,
Pagano Michele
Publication year - 2011
Publication title -
embo reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.584
H-Index - 184
eISSN - 1469-3178
pISSN - 1469-221X
DOI - 10.1038/embor.2011.62
Subject(s) - mitosis , mcl1 , microbiology and biotechnology , apoptosis , biology , mechanism (biology) , genetics , gene , downregulation and upregulation , philosophy , epistemology
Evidence for the destruction of the anti‐apoptotic protein MCL1 during prolonged mitotic arrest comes from three papers, one in The EMBO Journal and two in Nature , thus shedding light on the mechanism of apoptosis induction under these conditions.