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Receptor for advanced glycation end products binds to phosphatidylserine and assists in the clearance of apoptotic cells
Author(s) -
He Mei,
Kubo Hiroshi,
Morimoto Konosuke,
Fujino Naoya,
Suzuki Takaya,
Takahasi Toru,
Yamada Mitsuhiro,
Yamaya Mutsuo,
Maekawa Tomoyuki,
Yamamoto Yasuhiko,
Yamamoto Hiroshi
Publication year - 2011
Publication title -
embo reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.584
H-Index - 184
eISSN - 1469-3178
pISSN - 1469-221X
DOI - 10.1038/embor.2011.28
Subject(s) - phosphatidylserine , glycation , apoptosis , microbiology and biotechnology , receptor , chemistry , rage (emotion) , biochemistry , biology , neuroscience , phospholipid , membrane
Clearance of apoptotic cells is necessary for tissue development, homeostasis and resolution of inflammation. The uptake of apoptotic cells is initiated by an ‘eat‐me’ signal, such as phosphatidylserine, on the cell surface and phagocytes recognize the signal by using specific receptors. In this study, we show that the soluble form of the receptor for advanced glycation end products (RAGE) binds to phosphatidylserine as well as to the apoptotic thymocytes. RAGE‐deficient ( Rage −/− ) alveolar macrophages showed impaired phagocytosis of apoptotic thymocytes and defective clearance of apoptotic neutrophils in Rage −/− mice. Our results indicate that RAGE functions as a phosphatidylserine receptor and assists in the clearance of apoptotic cells.