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Nuclear IGF1R is a transcriptional co‐activator of LEF1/TCF
Author(s) -
Warsito Dudi,
Sjöström Sylvia,
Andersson Sandra,
Larsson Olle,
Sehat Bita
Publication year - 2012
Publication title -
embo reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.584
H-Index - 184
eISSN - 1469-3178
pISSN - 1469-221X
DOI - 10.1038/embor.2011.251
Subject(s) - insulin like growth factor 1 receptor , transcription factor , enhancer , biology , microbiology and biotechnology , cyclin d1 , nuclear receptor , activator (genetics) , nuclear export signal , receptor , gene , genetics , cell nucleus , cytoplasm , cell cycle , growth factor
Recent findings suggest that nuclear IGF1R binds to enhancer regions and functions as a transcriptional cofactor. However, the downstream transcriptional regulators of this pathway remain to be defined. Here, we show that nuclear IGF1R associates with the transcription factor LEF1 and increases promoter activity of LEF1 downstream target genes cyclin D1 and axin2 . Furthermore, nuclear IGF1R augments protein levels of cyclin D1 and axin2. Our findings suggest a novel function for IGF1R, thus further emphasizing the important role of this receptor in cancer biology.