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Xenopus paraxial protocadherin inhibits Wnt/β‐catenin signalling via casein kinase 2β
Author(s) -
Kietzmann Anja,
Wang Yingqun,
Weber Dominik,
Steinbeisser Herbert
Publication year - 2012
Publication title -
embo reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.584
H-Index - 184
eISSN - 1469-3178
pISSN - 1469-221X
DOI - 10.1038/embor.2011.240
Subject(s) - xenopus , protocadherin , wnt signaling pathway , microbiology and biotechnology , gastrulation , casein kinase 1 , biology , beta catenin , catenin , chemistry , cadherin , kinase , signal transduction , protein kinase a , cell , genetics , gene , embryo , embryogenesis
Xenopus paraxial protocadherin (PAPC) regulates cadherin‐mediated cell adhesion and promotes the planar cell polarity (PCP) pathway. Here we report that PAPC functions in the Xenopus gastrula as an inhibitor of the Wnt/β‐catenin pathway. The intracellular domain of PAPC interacts with casein kinase 2 beta (CK2β), which is part of the CK2 holoenzyme. The CK2α/β complex stimulates Wnt/β‐catenin signalling, and the physical interaction of CK2β with PAPC antagonizes this activity. By this mechanism, PAPC restricts the expression of Wnt target genes during gastrulation. These experiments identify a novel function of protocadherins as regulators of the Wnt pathway.