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Structural insights into the activation of RIG‐I, a nanosensor for viral RNAs
Author(s) -
Jiang QiuXing,
Chen Zhijian J
Publication year - 2012
Publication title -
embo reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.584
H-Index - 184
eISSN - 1469-3178
pISSN - 1469-221X
DOI - 10.1038/embor.2011.239
Subject(s) - innate immune system , rig i , rna , rna silencing , cytosol , microbiology and biotechnology , nanosensor , biology , immune system , virology , computational biology , rna interference , nanotechnology , gene , biochemistry , genetics , materials science , enzyme
RIG‐I detects cytosolic viral dsRNA and initiates antiviral innate immune responses. Four recent reports of crystal structures that enlighten how RIG‐I is activated and recognizes RNA are discussed.