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Wnts need a p(assport)24 to leave the ER
Author(s) -
Palmer Lucy,
Vincent JeanPaul,
Beckett Karen
Publication year - 2011
Publication title -
embo reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.584
H-Index - 184
eISSN - 1469-3178
pISSN - 1469-221X
DOI - 10.1038/embor.2011.222
Subject(s) - golgi apparatus , wnt signaling pathway , microbiology and biotechnology , endoplasmic reticulum , chemistry , biology , signal transduction
Wnts are secreted through a dedicated exocytic pathway, which has been only partly characterized. Here, Palmer and colleagues comment on two recent reports by the groups of K. Basler and M. Boutros, respectively, in which they show that p24 proteins take part in this exocytic route and are required for Wnt exit from the ER to the Golgi.